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新闻中心 Top-Peptide

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抗菌肽目录丨多肽合成定制

发布时间:2014-2-26 11:21:59  浏览次数:

 抗菌肽库(antimicrobial peptides) 是淘普生物(Top )科研团队打造的特色多肽库之一,是国内为数不多的品种齐全、质量优质、价格合理的多肽库,目前收录近二十种抗菌肽,并已经得到客户的好评。Top将继续挖掘更多的抗菌肽,致力服务于国内科研机构和各大院校。
1 抗菌肽的概念和分类
抗菌肽(antimicrobial peptides) 是具有抗菌活性短肽的总称。1975 年瑞典家G. B o m a n等人等从惜古比天蚕(Hyatophoracecropia) 蛹中诱导分离得到一种杀菌肽, 并将其命名为cecropin 。此后, 许多抗菌肽相继被分离、纯化。一些抗菌肽的氨基酸一级结构和基因序列得到确定。80年代, 有关抗菌肽的研究主要集中在大型的昆虫。90年代以来, 在继续对大型昆虫进行研究的同时, 又扩展到一些小型昆虫和其它无脊椎及脊椎动物, 抗菌肽已成为免疫学和分子生物学研究的热点。迄今为止,在不同动物组织中已发现了很多具有抗菌作用的蛋白质和多肽,已有70多种抗菌多肽的结构被测定,抗菌肽的概念得到了极大的扩展。
根据抗菌肽的结构,可将其分为 5 类:(1)单链无半胱氨酸残基的α-螺旋,或由无规卷曲连接的两段α-螺旋组成的肽;(2)富含某些氨基酸残基但不含半胱氨酸残基的抗菌肽;(3)含1 个二硫键的抗菌多肽;(4)有2 个或2 个以上二硫键、具有β -折叠结构的抗菌肽;(5)由其它已知功能的较大的多肽衍生而来的具有抗菌活性的肽。其中最早分离到的Cecropins和从非洲爪蟾中分离到的Magainins等属于第一类抗菌肽,通常也将其称为Cecropin类抗菌肽,目前对此类抗菌肽的研究也较深入。

以下是目前Top公司拥有的抗菌肽目录。

 Cat No  Name  sequence
 Tp1101  Hepcidin-25 (human)

 H-Asp-Thr-His-Phe-Pro-Ile-Cys-Ile-Phe-Cys-Cys-Gly-Cys-Cys-His-Arg-Ser-Lys-Cys-Gly-Met-Cys-Cys-Lys-Thr-OH

Trifluoroacetate salt (Disulfide bonds between Cys and Cys²³/Cys11 and Cys¹³/Cys¹¹ and Cys¹⁹ /Cys¹ and Cys²²)

 Tp1102  Biotinyl-Hepcidin-25 (human)

 Biotinyl-Asp-Thr-His-Phe-Pro-Ile-Cys-Ile-Phe-Cys-Cys-Gly-Cys-Cys-His-Arg-Ser-Lys-Cys-Gly-Met-Cys-Cys-Lys-Thr-OH

 Trifluoroacetate salt Disulfide bonds between Cys⁷ and Cys²³/Cys¹⁰and Cys¹³/Cys¹¹ and Cys¹ ⁹/Cys¹ ⁴and Cys²²)

 Tp1102  Biotinyl-Hepcidin-25 (human)

 Biotinyl-Asp-Thr-His-Phe-Pro-Ile-Cys-Ile-Phe-Cys-Cys-Gly-Cys-Cys-His-Arg-Ser-Lys-Cys-Gly-Met-Cys-Cys-Lys-Thr-OH

Trifluoroacetate salt Disulfide bonds between Cys⁷ and Cys²³/Cys¹⁰and Cys¹³/Cys¹¹ and Cys¹ ⁹/Cys¹ ⁴and Cys²²)

 Tp1103  Defensin HNP-3 (human)

 H-Asp-Cys-Tyr-Cys-Arg-Ile-Pro-Ala-Cys-Ile-Ala-Gly-Glu-Arg-Arg-Tyr-Gly-Thr-Cys-Ile-Tyr-Gln-Gly-Arg-Leu-Trp-Ala-Phe-Cys-Cys-OH

Trifluoroacetate salt (Disulfide bonds between Cys² and Cys³⁰/Cys ⁴and Cys¹⁹/Cys⁹and Cys²⁹)

 Tp1104  Defensin HNP-2 (human)

 H-Cys-Tyr-Cys-Arg-Ile-Pro-Ala-Cys-Ile-Ala-Gly-Glu-Arg-Arg-Tyr-Gly-Thr-Cys-Ile-Tyr-Gln-Gly-Arg-Leu-Trp-Ala-Phe-Cys-Cys-OH

Trifluoroacetate salt(Disul fide bonds between Cys¹and Cys²⁹/Cys³and Cys¹⁸/Cys⁸and Cys²⁸ )

 Tp1105  Defensin HNP-1 (human)

 H-Ala-Cys-Tyr-Cys-Arg-Ile-Pro-Ala-Cys-Ile-Ala-Gly-Glu-Arg-Arg-Tyr-Gly-Thr-Cys-Ile-Tyr-Gln-Gly-Arg-Leu-Trp-Ala-Phe-Cys-Cys-OH

Disulfide bonds between Cys²and Cys³⁰/Cys⁴and Cys¹⁹/Cys ⁹andCys²⁹)

 Tp1106  Magainin I  H-Gly-Ile-Gly-Lys-Phe-Leu-His-Ser-Ala-Gly-Lys-Phe-Gly-Lys-Ala-Phe-Val-Gly-Glu-Ile-Met-Lys-Ser-OH
 Tp1107  Bombinin-LikePeptide (BLP-1)  H-Gly-Ile-Gly-Ala-Ser-Ile-Leu-Ser-Ala-Gly-Lys-Ser-Ala-Leu-Lys-Gly-Leu-Ala-Lys-Gly-Leu-Ala-Glu-His-Phe-Ala-Asn-NH2
 Tp1108  Tuftsin  H-Thr-Lys-Pro-Arg-OH Aetate salt
 Tp1109  Indolicidin  H-Ile-Leu-Pro-Trp-Lys-Trp-Pro-Trp-Trp-Pro-Trp-Arg-Arg-NH2
 Tp1110  CecropinA (1-7)
MelittinA(2-9)amie
 H-Lys-Trp-Lys-Leu-Phe-Lys-Lys-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-NH2 Trifluoroacetate salt
 Tp1111  Acetyl-Adhesin
(1025-1044)amide
 Ac-Gln-Leu-Lys-Thr-Ala-Asp-Leu-Pro-Ala-Gly-Arg-Asp-Glu-Thr-Thr- Ser-Phe-Val-Leu-Val-NH2
  Tp1112  α-Defensin 6  H-Ala-Phe-Thr-Cys-His-Cys-Arg-Arg-Ser-Cys-Tyr-Ser-Thr-Glu-Tyr-Ser-Tyr-Gly-Thr-Cys-Thr-Val-Met-Gly-Ile-Asn-His-Arg-Phe-Cys-Cys-Leu-OH Trifluoroacetate salt (Disulfide bonds between Cys ⁴and Cys³¹/Cys⁶and Cys²⁰/Cys¹⁰and Cys³⁰)
  Tp1113  Brevinin-1  H-Phe-Leu-Pro-Val-Leu-Ala-Gly-Ile-Ala-Ala-Lys-Val-Val-Pro-Ala-Leu-Phe-Cys-Lys-Ile-Thr-Lys-Lys-Cys-OH (Disulfide bond)
  Tp1114  Ranalexin  H-Phe-Leu-Gly-Gly-Leu-Ile-Lys-Ile-Val-Pro-Ala-Met-Ile-Cys-Ala-Val-Thr-Lys-Lys-Cys-OH (Disulfide bond)
  Tp1115  CRAMP (mouse)  H-Gly-Leu-Leu-Arg-Lys-Gly-Gly-Glu-Lys-Ile-Gly-Glu-Lys-Leu-Lys-Lys-Ile-Gly-Gln-Lys-Ile-Lys-Asn-Phe-Phe-Gln-Lys-Leu-Val-Pro-Gln-Pro-Glu-Gln-OH Trifluoroacetate salt
  Tp1116  KR-12 (human)  H-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-NH2
Trifluoroacetate salt
  Tp1117  Cecropin P1 (porcine)  H-Ser-Trp-Leu-Ser-Lys-Thr-Ala-Lys-Lys-Leu-Glu-Asn-Ser-Ala-Lys-Lys-Arg-Ile-Ser-Glu-Gly-Ile-Ala-Ile-Ala-Ile-Gln-Gly-Gly-Pro-Arg-OH
  Tp1118  Tachyplesin I  H-Lys-Trp-Cys-Phe-Arg-Val-Cys-Tyr-Arg-Gly-Ile-Cys-Tyr-Arg-Arg-Cys-Arg-NH2 (Disulfide bonds between Cys³and Cys¹ ⁶/Cys⁷and Cys¹²)
  Tp1119  CathepsinG (77-83)  H-His-Pro-Gln-Tyr-Asn-Gln-Arg-OH
  Tp1120  Pseudin-2  H-Gly-Leu-Asn-Ala-Leu-Lys-Lys-Val-Phe-Gln-Gly-Ile-His-Glu-Ala-Ile-Lys-Leu-Ile-Asn-Asn-His-Val-Gln-OH Trifluoroacetate salt
  Tp1121  LL-37  H-Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-NH2 Trifluoroacetate salt
  Tp1122  Seminalplasmin Fragment
(SPF)
 H-Pro-Lys-Leu-Leu-Lys-Thr-Phe-Leu-Ser-Lys-Trp-Ile-Gly-OH
  Tp1123  Dermaseptin  H-Ala-Leu-Trp-Lys-Thr-Met-Leu-Lys-Lys-Leu-Gly-Thr-Met-Ala-Leu-His-Ala-Gly-Lys-Ala-Ala-Leu-Gly-Ala-Ala-Ala-Asp-Thr-Ile-Ser-Gln-Gly-Thr-Gln-OH